Human Clinical Study: Prebiotic PreforPro^® Shown to Positively Impact Gut Microbiota

In a study involving 43 participants aged 18-65, researchers found that 28-days of PreforPro consumption favorably modified several bacterial species, including increased populations of the genera Eubacterium, one of the most abundant genera in the healthy human gut. Moreover, a reduction was observed in the circulating pro-inflammatory cytokine Il-4, which is correlated with autoimmune and allergic responses. These data highlight the potential of bacteriophages for selective modification of targeted microbial species without inducing dysbiosis.

In conclusion, according to the authors, “bacteriophage consumption caused minimal disruption to the gut microbiota but did elicit minor changes which may be viewed as beneficial overall…and increases in fermentative taxa capable of butyrate production suggest a shift towards a healthier gut environment.”